Ezra D. Alexander was born in Bloomington, Indiana. He graduated from Bloomington High School in 1910. Ezra entered Indiana University in the fall of 1910 and graduated with an A.B. degree in 1917. He received his M.D. degree from the Medical School of Indiana University in 1919 and went on to practice medicine in Indianapolis, Indiana. Alexander took part in the establishment of Kappa Alpha Nu and served several terms as a member of the Grand Board of Directors of Kappa Alpha Psi.